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Request for Applications: Advancing the Evidence and Implementation of Activity-Based Therapy to Enhance Neuro-restoration in Individuals with Spinal Cord Injury
Note: Documents for this RFA were originally uploaded September 2019 and may contain references of Praxis as RHI or Rick Hansen Institute.
Praxis Spinal Cord Institute is a Canadian-based not-for-profit organization that drives innovation in spinal cord injury (SCI) research and care. By facilitating an international network of researchers, healthcare professionals, entrepreneurs, investors, people with SCI, and their supporters, we strive to improve the lives of people living with SCI in Canada and around the world.
The objective of the Praxis’ Cure Program is to further our understanding of the biology and physiology of SCI and to develop promising therapies for neuro-restoration in acute and chronic SCI.
Description of this RFA
Definition of ABT
Activity-based therapy (ABT) is defined as interventions that target activation of the neuromuscular system below the level of the lesion, with the goal of retraining the nervous system to recover a specific motor task1. Many existing technologies (e.g. functional electrical stimulation [FES]) and emerging technologies (e.g. epidural stimulation, robot assisted gait training) are used to provide neuromuscular activation below the level of the lesion, task specific training, or both. ABT that combines task specific training with neuromuscular activation below the level of the lesion offers possibilities for neuro-recovery impacting an individual’s motor, sensory, and/or autonomic function (e.g. standing and walking, grasping and reaching, heart rate, blood pressure, respiratory functions, bowel and bladder function, sexual function, etc.). However, there is limited evidence on how to administer ABT (e.g. timing, method, dose) and the impact on outcomes, both of which need to be addressed to advance SCI care.
Focus of this RFA
In 2012, Praxis supported the formation of a national community of practice in the area of standing and walking measures at Canadian SCI rehabilitation centres participating in the Rick Hansen SCI Registry. Since then, ten of the SCI rehabilitation centres have started to administer a set of standardized outcome measures and stage patients to document their walking ability. Through this work and other network activities, ABT was identified as a Praxis priority area for neuro-restoration, which led to a stakeholder engagement in early 2019 to create a Canadian ABT Strategy for SCI. Themes from the Canadian ABT Strategy along with additional stakeholder input have informed the priority areas for this RFA in research and care.
Applications from within and outside of Canada are invited that address one or more of the following priority areas involving human subjects and that have the potential to be implemented across the SCI continuum:
- Creating a network to facilitate dialogue between hospital and community groups to support the implementation of ABT for individuals with SCI
- Developing methods for tracking ABT (e.g. define measure of ‘intensity’ for ABT, standardize measures for data collection, use data to answer questions about outcomes or evaluate potential benefits of ABT)
- Studying optimal timing, methods, and dose of ABT (e.g. summarize current research evidence, build neuro-physiological evidence, evaluate technologies (e.g. FES, etc.) to provide ABT, develop decision support tools for an individualized approach)
- Developing and implementing clinical ABT protocols
Preference (if applicable)
- Projects that use the International SCI Data Sets and/or the NIH National Institute of Neurological Disorders and Stroke SCI Common Data Elements
- Projects that will make data available to other investigators (see section on “Preservation, Retention and Sharing” in Tri-Agency Statement of Principles on Digital Data Management)
- Projects that are collaborative and involve multiple centres
- Projects that consider the inclusion of sex and gender in project methodology
- Projects that offer payment to Patient Partners in Research (see CIHR)
Note on MaRS Innovation Challenge
To support the priority area of methods for tracking ABT activities across the care continuum, we are also launching another competition with MaRS. The objective of the MaRS Innovation Challenge is to develop new or validate existing technologies with commercialization potential that quantify clinical measures (intensity, dosage, and/or total amount of targeted body systems) and outcome measures (change in health outcomes, e.g. neuro-recovery, autonomic function, etc.).
For those interested in this area, we encourage you to apply to the MaRS Innovation Challenge which will be launched later in the fall.
Award Amount and Duration
The total amount available for this competition is $300,000 CDN.
Up to 3 awards will be funded, each for a maximum of 24 months.
The award is to support project activities. Ineligible project expenses include:
- Capital expenses (e.g. computers, office equipment, furniture, and fixtures, etc.)
- Indirect expenses (overhead, administrative cost)
- Travel and accommodation expenses in excess of rates as per RHI’s policy (see Appendix 1)
- Activities that are not part of the project
The Principal Applicant must:
- Be affiliated or be partnered with an institution, either within and outside of Canada, eligible to hold Praxis funds (see below)
- Have an academic, clinical, or research appointment which allows him/her to pursue independent projects, including the proposed project
- Engage in independent research activities for the entire duration of the funding
- Accept Praxis’ conditions of funding (see Appendix 1)
Applicants must disclose all real or perceived conflicts of interest.
The Host Institution must:
- Be a qualified donee registered with Canada Revenue Agency
- Not be a private, for-profit organization
All Project Team Members must have the support of their organization to participate in the project.
|Key Dates||Target Date|
|RFA Opens||September 17, 2019|
|Registration of Intent (ROI)||November 4, 2019 @ 23:59 PST|
|Deadline to Apply||December 9, 2019 @ 23:59 PST|
|Review Process||December 2019 – January 2020|
|Notice of Decision|
Step 1: Registration of Intent
Applicants must register their intent to submit a full application by emailing with the following:
- Name of Applicant
- Name of Host Institution
- Proposed Project Title
- Proposed Total Budget
Step 2: Full Application
Applicants must complete the Application Cover (Appendix 2) and include the following:
Detailed application instructions are provided in Appendix 3.
- Project Summary
- Lay Summary
- Scientific Summary/Abstract
- Proposal (10 pages maximum for sections a – e and g, excluding appendices and attachments)
- Significance of Issue(s) to be Addressed by Project
- Project Methodology
- Expected Outcomes and Scalability
- Impact on Stakeholders and Knowledge Translation
- Risk Analysis
- Budget Request and Work Plan
- Qualifications of Team Members
Formatting and Submission
Please format your application as follows:
- Font: Calibri 11-point
- Margin: 1.0 inch all sides
- Spacing: 1.5 line
- Header: Insert name of Principal Applicant (Last, First) on the right-hand side
- Footer: Insert page number on the right-hand side
- Budget: Use the RHI template (Appendix 6)
- Curriculum Vitae (CV): Those formatted for other institution (e.g. CIHR) may be used
Please compile your application into a single and indexed (i.e. include a table of contents) PDF and submit it electronically to before the deadline. You will receive an acknowledgement of your application within 2 days of submission. Please contact us at the same email address if you do not receive an acknowledgement after that time.
Applicants may withdraw their application at any time prior to the closing date and time. At closing, all incomplete and late applications will be rejected.
A team of external reviewers will evaluate the submitted applications using the selection criteria outlined below.
- Merit and Feasibility: Is the project within the scope of the RFA? Is there evidence of excellence and scientific merit of the project? Are the project’s objectives realistic given the project’s scope, schedule and identified resources?
- Strategic Alignment: Does the proposed project alignwith RHI’s strategic plan, vision, and mission?
- Achievable Value: Is the output or outcome meaningful and of value to the relevant stakeholders? Is there evidence of meaningful engagement with people with SCI in the project design to make sure the outcome is meaningful to the SCI community?
- Fulfilling a Defined Need: Does this project address a clearly defined need and is the solution innovative, transformative, and/or disruptive? Is the potential impact of the project clearly articulated?
- Evaluation Plan: How will the outcomes be measured?
- Operational Readiness: Is the applicant appropriately trained, resourced, and capable of carrying out the proposed project? Is there evidence of meaningful involvement of the team to successfully carry out the project?
All questions regarding this RFA are to be directed to Praxis by email at email@example.com
1Behrman et al. J Neurol Phys Ther. 2017 July; 41(Suppl 3 IV STEP Spec Iss): S39-S45