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Effects of Biological Sex on Access to Care and Outcomes After Acute Spinal Cord Injury

Julio C. Furlan, Tian Shen, Dilnur Kurban

DOI: https://doi.org/10.1212/WNL.0000000000213996

Background and Objectives

Preclinical studies have documented potential neuroprotective effects of estrogen and progesterone, but the impact of biological sex on outcomes after traumatic spinal cord injury (tSCI) remains incompletely understood. This study compared male and female age-stratified subgroups, presumably corresponding to premenopausal, and postmenopausal states, regarding access to optimal care and their outcomes after tSCI.

Discussion

The study found that female and male subgroups had similar in-hospital mortality rates and comparable motor and sensory score changes across all age groups when optimal care was applied. These findings suggest that biological sex does not significantly affect in-hospital mortality or neurologic recovery after tSCI, supporting the notion that sex equity in management strategies promotes equal outcomes.

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